WHO Recommends Two New Drugs, Baricitinib And Sotrovimab, To Treat Covid-19

| Updated: January 27, 2022 7:17 pm

Pic credit: Hanif Sindhi

The World Health Organisation (WHO) has recommended two new drugs for Covid-19 — Baricitinib and Sotrovimab, providing yet more options for treating the disease. The extent to which these medicines will save lives depends on how widely available and affordable they will be.

The first drug, Baricitinib, is strongly recommended for patients with severe or critical Covid-19.It is an oral drug, used in the treatment of rheumatoid arthritis. Baricitinib provides an alternative to other arthritis drugs called Interleukin-6 receptor blockers, recommended by WHO in July 2021.

WHO has also conditionally recommended the use of a monoclonal antibody drug, Sotrovimab, for treating mild or moderate Covid-19 in patients who are at high risk of hospitalization. This includes patients who fall in the older age group, immunocompromised, having underlying conditions like diabetes, hypertension, and obesity, and those unvaccinated.

Sotrovimab is an alternative to casirivimab-imdevimab, a monoclonal antibody cocktail recommended by WHO in September 2021. Studies are ongoing on the effectiveness of monoclonal antibodies against Omicron, but early laboratory studies show that Sotrovimab retains its activity.

The recommendations are based on evidence from seven trials involving over 4,000 patients with non-severe, severe, and critical Covid-19.

WHO is in discussions with manufacturers to secure global supply capacity and equitable and sustainable access to the newly recommended therapeutics. The Access to COVID-19 Tools Accelerator (ACT-A) Therapeutics pillar has been engaging with pharmaceutical companies to seek comprehensive access plans for low- and middle-income countries, so that these treatments can be rapidly deployed everywhere, not just in rich countries. The ACT-A is also looking to expand licensing scope to make the products more affordable.

The two newly recommended drugs – Baricitinib and Sotrovimab – have been invited for WHO prequalification, which assesses the quality, efficacy and safety of priority health products to increase access in lower income countries.

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